These are two very similar medications that are in the glucocorticoid class of medications. Glucocorticoids are naturally occurring bodily hormones stated in the area of the adrenal gland called the adrenal cortex. The adrenal gland is situated in the space behind the abdominal tooth cavity called the retro-peritoneum and is adjacent to the upper end of the kidney, hence its name adrenal. The adrenal gland comprises of the outer aspect called the cortex, and the inner part called the medulla Prednisolone. The cortex is primarily an endocrine gland, meaning it produces bodily hormones that are released into the system, called corticosteroids. Cortisol is one of these corticosteroids whose function that includes stimulating the release of blood sugar from cells, and is called a glucocorticoid.

Many man-made and semi-synthetic medications are in the class called glucocorticoids. Two of these are prednisone and prednisolone. Prednisone is usually used as an mouth medication. It is livlier milligram for milligram than cortisol. One mg. of prednisone has about the same sexual strength as 5 mg of cortisol. The adrenal gland naturally releases about 20 mg of cortisol into the body daily. In patients with adrenal insufficiency a typical daily serving of prednisone to be used for hormone replacement therapy is 5 mg daily. Prednisone is not soluble in water, and so struggles to be given intravenously. Prednisone taken orally is metabolized into prednisolone chemistry.

Prednisolone is also available as a medication. It is soluble in water, and so can be given intravenously, as well as which is injected into cells and joint spaces. Prednisolone is a widely used 4 glucocorticoid, and is also sometimes given orally. It is a common mouth preparation for children, as it is soluble and so can be absorbed in water and so made into syrup. Prednisolone is slightly livlier on a mg. for mg. basis than prednisone. About 4 mg or prednisolone is equivalent to 4 mg of prednisone and 20 mg of cortisol.